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  • Title: Amino acid alterations in a hydrophobic region of the TraT protein of R6-5 increase the outer membrane permeability of enteric bacteria.
    Author: Sukupolvi S, O'Connor D.
    Journal: Mol Gen Genet; 1987 Nov; 210(1):178-80. PubMed ID: 3323837.
    Abstract:
    Two insertion mutations, each introducing a new negatively charged amino acid residue into a hydrophobic region of the TraT protein coded by the F-like plasmid R6-5 caused significant alterations in outer membrane permeability of Escherichia coli and Salmonella typhimurium, so that strains carrying plasmids with either of these mutations became sensitive to hydrophobic antibiotics.
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