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  • Title: Reduced excretion of vasodilator prostaglandins in preeclampsia.
    Author: Minuz P, Covi G, Corsato M, Probitzer P, Spiazzi L, Paluani F, Degan M, Lechi C, Lechi A.
    Journal: Agents Actions Suppl; 1987; 22():175-81. PubMed ID: 3324706.
    Abstract:
    The role of prostaglandin (PG) system in preeclampsia (pre-E) was investigated. Urinary excretion of PGE2,6-keto PGF1 alpha,2,3 dinor 6-keto PGF1 alpha, TxB2 and 2,3-dinor-TxB2 and kallikrein were determined in 10 normotensive pregnant women and 14 with pre-E. 6-keto PGF1 alpha and 2,3-dinor 6-keto PGF1 alpha (the main renal and extrarenal metabolites of vasodilator PGI2) and PGE2 excretion was lower in pre-E. TxB2 metabolites in urine were similar in the two groups of women. Our data are consistent with the hypothesis of an imbalance between vasodilator and vasoconstrictor PGs in pre-E.
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