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  • Title: Ascending urinary tract infections in rats induced by Staphylococcus saprophyticus and Proteus mirabilis.
    Author: Hjelm E, Lundell-Etherden I, Mårdh PA.
    Journal: Acta Pathol Microbiol Immunol Scand B; 1987 Dec; 95(6):347-50. PubMed ID: 3326399.
    Abstract:
    Ascending pyelonephritis was induced by Staphylococcus saprophyticus and Proteus mirabilis both by inoculating the organisms separately and in combination into rat bladders. Bacterial cultures of tissue homogenates showed that pyelonephritis by both bacteria occurred significantly more often in rats where the two organisms were instilled concomitantly, suggesting a synergistic virulence between the two species. The antibody response to the different organisms was the same either the bacteria were instilled separately or in combination.
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