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  • Title: Stereoselective inhibition of chloride transport by loop diuretics in pancreatic beta-cells.
    Author: Sandström PE, Sehlin J.
    Journal: Eur J Pharmacol; 1987 Dec 15; 144(3):389-92. PubMed ID: 3326748.
    Abstract:
    The effects of loop diuretics on 36Cl- uptake was tested in isolated beta-cell-rich pancreatic islets. Bumetanide reduced the 36Cl- influx and the levorotatory form of ozolinone reduced both the influx and equilibrium content of 36Cl- in the islets, whereas the dextrorotatory form was largely inactive. The data suggest that the beta-cells are equipped with a loop diuretic-sensitive system for 36Cl- uptake and that this system is confined to a sterically well-defined structure.
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