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  • Title: [Down regulation of insulin receptors in the rat liver in aging].
    Author: Gatsko GG, Linnik IV.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1987 Dec; 73(12):1691-5. PubMed ID: 3327708.
    Abstract:
    No decrease in the specific binding of 125I-insulin in the liver plasmatic membranes in response to insulin administration (2 units per 100 g/w) occurred in 24-26 month old rats whereas the response was obvious in 5-6 month old animals. The older animals showed a less obvious response of insulin receptors to 2-week administration of the hormone.
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