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Title: The clinical pathology and pathophysiology of heartwater: a review. Author: Van Amstel SR, Guthrie AJ, Reyers F, Bertschinger H, Oberem PT, Killeen VM, Matthee O. Journal: Onderstepoort J Vet Res; 1987 Sep; 54(3):287-90. PubMed ID: 3329320. Abstract: This paper reviews the available literature on the clinical pathology and pathophysiology of heartwater and makes comparisons with unpublished results obtained from a recent study in experimentally-induced heartwater in calves. The pathophysiological changes seem to center on an increased capillary permeability the result of which is reflected most noticeably in cardiac and lung function. There is a marked drop in cardiac output in severe cases and some workers have recorded a severe drop in diastolic blood pressure in the advanced stage of the disease. Changes in lung function are variable, depending on the stage of the disease, and may change from a respiratory alkalosis in the early febrile stage to a respiratory acidosis in more advanced cases. The basic cause for the increased capillary permeability is not known. The main clinical pathological changes measured include a progressive anaemia, fluctuations in total and differential white cell count, of which an eosinopenia and a lymphocytosis are the most marked, increases in total bilirubin which coincide with darkening of plasma colour, and a drop in total serum proteins mostly shown in the albumin levels.[Abstract] [Full Text] [Related] [New Search]