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  • Title: Iron-Mineralization-Induced Mesoporous Metal-Organic Frameworks Enable High-Efficiency Synergistic Catalysis of Natural/Nanomimic Enzymes.
    Author: Huang S, Chen G, Ye N, Kou X, Zhang R, Shen J, Ouyang G.
    Journal: ACS Appl Mater Interfaces; 2020 Dec 23; 12(51):57343-57351. PubMed ID: 33296162.
    Abstract:
    Metal-organic frameworks (MOFs) have become a promising accommodation for enzyme immobilization and protection. However, the integration of multienzymes into MOFs may result in compromise of individual enzymatic activity. In this work, we report an iron mineralization strategy to facilely construct a mesoporous MOF, possessing excellent peroxidase-mimic bioactivity. Furthermore, the feasibility of in situ encapsulating natural enzymes within the developed mesoporous MOF nanozymes endows these natural/nanomimic enzyme hybrids with remarkably enhanced synergistic catalysis ability. Such activity enhancement is mainly due to (1) the fast flux rate of substances through the interconnected mesoporous channels and (2) the simultaneously increased loading amount of enzymes and iron within the MOFs caused by the iron mineralization process.
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