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  • Title: Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements.
    Author: Rabin M, Birnbaum D, Young D, Birchmeier C, Wigler M, Ruddle FH.
    Journal: Oncogene Res; 1987 Jul; 1(2):169-78. PubMed ID: 3329713.
    Abstract:
    Oncogenes have been implicated in tumorigenesis based on their localization to chromosomal sites associated with tumor-specific structural rearrangements. We have mapped the human ros1 (formerly mcf3) and mas1 oncogenes to the distal half of chromosome 6q, within a region frequently rearranged in malignant cells. Chromosomal mapping of these two new human transforming genes may help elucidate the involvement of the long arm of chromosome 6 in diverse tumor types.
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