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  • Title: [Mesalazine-induced myocarditis].
    Author: Koh Y, Nagaya T, Saegusa H, Ikeuchi H, Kodama R, Ushimaru H.
    Journal: Nihon Shokakibyo Gakkai Zasshi; 2020; 117(12):1093-1099. PubMed ID: 33298675.
    Abstract:
    A 30-year-old man presented with constipation and abdominal pain. He was suspected of having ulcerative colitis, and administration of 2400mg/day of oral mesalazine was initiated. After 10 days of treatment, he experienced fever and chest pain. Blood examination, electrocardiography, and cardiac ultrasonography revealed elevated cardiac enzymes, ST-segment elevation, and diffuse hypokinesis, respectively. Mesalazine-induced acute myocarditis was diagnosed based on a positive drug-induced lymphocyte stimulation test and the absence of other myocarditis-causing conditions. Prompt cessation of mesalazine quickly improved his heart function and test results. Although rare, clinicians should consider the possibility of cardiac adverse events caused by mesalazine.
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