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  • Title: Simultaneous voltammetric determination of epinephrine and acetaminophen using a highly sensitive CoAl-OOH/reduced graphene oxide sensor in pharmaceutical samples and biological fluids.
    Author: Wu C, Li J, Liu X, Zhang H, Li R, Wang G, Wang Z, Li Q, Shangguan E.
    Journal: Mater Sci Eng C Mater Biol Appl; 2021 Feb; 119():111557. PubMed ID: 33321621.
    Abstract:
    For this study, three novel types of sensors comprised of CoAl-layered double oxyhydroxide (CoAl-LDH), CoAl-LDH/reduced graphene oxide (rGO), and CoAl-OOH/rGO nanosheets were successfully fabricated on glassy carbon electrodes (GCEs) and employed for the electrochemical detection of epinephrine (EP) and acetaminophen (AC). Interestingly, we found that the CoAl-OOH/rGO/GCE was more suitable for the determination of EP and AC in contrast to the CoAl-LDH and CoAl-OOH/rGO sensors. Differential pulse voltammetry results revealed that the CoAl-OOH/rGO/GCE delivered excellent electrocatalytic activity. The sensitivities and detection limits for the simultaneous measurement of EP and AC were 12.2 μA μM-1 cm-2, 0.023 μM L-1, and 4.87 μA μM-1 cm-2, 0.058 μM L-1, respectively. Especially, the as-obtained CoAl-OOH/rGO/GCE was successfully utilized for the detection in pharmaceutical samples and biological fluids with satisfactory results. Owing to its outstanding electrocatalytic activity and superior sensitivity, the CoAl-OOH/rGO/GCE could be beneficial to construct a promising electrochemical sensor for the detection of EP and AC.
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