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Title: Influence of single and double immunomagnetic depletion on the hemopoietic capacity of marrow in patients with advanced neuroblastoma submitted to autologous bone marrow transplantation. Author: Lopez M, Zucker JM, Urresola R, Douay L, Quintana E, Kemshead J, Gorin NC, Vilcoq JR. Journal: Bone Marrow Transplant; 1987 Dec; 2(4):413-9. PubMed ID: 3332188. Abstract: Eighteen marrows from 16 patients with advanced neuroblastoma were submitted to a single or double immunomagnetic depletion procedure to purge them of tumor cells. Analysis of results showed that the CFU-GM recoveries were 59% +/- 16 (SE) and 33% +/- 16 after one or two cycles of incubation with microspheres. This led to yields of 7.8 x 10(4) and 4.1 x 10(4) CFU-GM available per kg body weight, respectively. Successful engraftment was demonstrated in all evaluable patients. However, some patients had delayed hematologic recoveries, particularly for platelets.[Abstract] [Full Text] [Related] [New Search]