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  • Title: Synthetic trypanocides: growth-inhibiting properties of new 1,2,3,4-tetrahydrocarbazoles on Trypanosoma cruzi.
    Author: Albónico SM, Assem ME, Benages IA, Montiel AA, Pizzorno MT, Docampo R, Stoppani AO.
    Journal: Rev Argent Microbiol; 1987; 19(3):121-4. PubMed ID: 3332382.
    Abstract:
    Several new 1,2,3,4-tetrahydrocarbazole, 5,6-dihydrobenzo(alpha) carbazole, 3-methylindole and substituted benzimidazolyl compounds were synthesized and assayed for their action on growth of Trypanosoma cruzi, cultured in Warren's liquid medium. 6-chloro and 6,8-dichloro-N-(1-ethyl-N-diethylamino)-1,2,3,4-tetrahydrocarbazole++ fumarate resulted the more active in inhibiting growth of the parasite. The new compounds were apparently more effective than those prepared previously by Poliakoff et al. (5).
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