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  • Title: Expression of human interferon alpha H, an interferon with two potential asparagine-linked glycosylation sites.
    Author: Zhao XX, Daugherty BL, Schwartz B, Maeda S, Pestka S.
    Journal: J Biol Regul Homeost Agents; 1987; 1(3):103-8. PubMed ID: 3332544.
    Abstract:
    Of the large number of human alpha interferon genes identified, only one, Hu-IFN-alpha H, contains potential asparagine-linked glycosylation sites. With the use of a new vector that permits convenient expression, site-specific mutation, and DNA sequencing, Hu-IFN-alpha H was expressed in Escherichia coli. The bacterial product which is not glycosylated is fully active demonstrating that the carbohydrate on this species is not required for antiviral activity.
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