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Title: [Pulmonary ventilation function parameters of children aged 5-14 years in Kunming, China: a comparative analysis of measured values versus predicted values based on Zapletal equation].
Author: Yang J, Fu HM, Bai TZ, Wang F, Zhang O, Zhang SD, Nie WS.
Journal: Zhongguo Dang Dai Er Ke Za Zhi; 2020 Dec; 22(12):1313-1319. PubMed ID: 33328003.
Abstract:
OBJECTIVE: To study the percentage of the measured values of the main pulmonary ventilation function parameters in their predicted values based on Zapletal equation among healthy children aged 5-14 years in Kunming, China, and to provide a basis for accurate judgment of pulmonary ventilation function in clinical practice. METHODS: A total of 702 healthy children aged 5-14 years (352 boys and 350 girls) from Kunming were enrolled. The Jaeger spirometer was used to measure the nine indices:forced vital capacity (FVC), forced expiratory volume in one second (FEV1), ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC), maximal mid-expiratory flow (MMEF), forced expiratory flow at 25% of forced vital capacity (FEF25), forced expiratory flow at 50% of forced vital capacity (FEF50), forced expiratory flow at 75% of forced vital capacity (FEF75), peak expiratory flow (PEF), and maximal voluntary ventilation (MVV). The values obtained from the Zapletal equation of predicted values provided by the spirometer were used as the predicted values of children, and the percentage of measured values in predicted values was calculated. RESULTS: In the 702 children, the percentages of the measured values of the main pulmonary ventilation function parameters PEF, FVC, FEV1, FEV1/FVC, and MVV in their predicted values fluctuated from 102% to 114%, 94% to 108%, 98% to 113%, 98% to 107%, and 141% to 183% respectively. As for the main airway velocity parameters, the percentages of the measured values of FEF25, FEF50, FEF75, and MMEF in their predicted values fluctuated from 98% to 116%, 85% to 102%, 71% to 98%, and 83% to 100% respectively. The percentages of the measured values of PEF, FVC, FEV1, FEV1/FVC, MVV, FEF25, FEF50, FEF75, and MMEF in their predicted values had the lower limits of normal of 88.2%, 88.4%, 92.0%, 94.4%, 118.5%, 82.9%, 70.0%, 62.1%, and 70.1% respectively. CONCLUSIONS: There are differences between pulmonary ventilation function parameter levels and normal values provided by Zapletal equation in healthy children aged 5-14 years in Kunming. As for the pulmonary ventilation function parameters of PEF, FVC, FEV, FEV1/FVC, MVV, FEF25, FEF50, FEF75, and MMEF in these children, the lower limits of normal of measured values in predicted values may be determined as 88.2%, 88.4%, 92.0%, 94.4%, 118.5%, 82.9%, 70.0%, 62.1%, and 70.1% respectively. 目的: 研究昆明市5~14岁健康儿童肺通气功能主要参数实测值占Zapletal方程式预计值的百分比，为临床准确判断肺通气功能提供依据。方法: 纳入昆明市5~14岁健康儿童702名，其中男352名，女350名。采用Jaeger肺功能仪测定用力肺活量（FVC）、第1秒用力呼气容积（FEV1）、1秒率（FEV1/FVC）、最大中期呼气流量（MMEF）、用力呼气25%肺活量时瞬时流量（FEF25）、用力呼气50%肺活量时瞬时流量（FEF50）、用力呼气75%肺活量时瞬时流量（FEF75）、最高呼气流量（PEF）、每分钟最大通气量（MVV），共9项指标，以肺功能仪中提供的Zalpetal预计值公式得出的数值作为所选择儿童的预计值，计算其实测值占预计值的百分比。结果: 在702名儿童中，肺通气功能主要参数PEF、FVC、FEV1、FEV1/FVC、MVV实测值占预计值百分比的均值分别波动于102%~114%、94%~108%、98%~113%、98%~107%、141%~183%。气道流速指标功能参数FEF25、FEF50、FEF75、MMEF实测值占预计值百分比分别波动于98%~116%、85%~102%、71%~98%、83%~100%。各参数PEF、FVC、FEV1、FEV1/FVC、MVV、FEF25、FEF50、FEF75、MMEF实测值占Zapletal方程式预计值百分比的下限分别为88.2%、88.4%、92.0%、94.4%、118.5%、82.9%、70.0%、62.1%、70.1%。结论: 昆明地区5~14岁健康儿童肺通气功能参数水平与Zapletal方程式提供的正常值存在一定差异；该地区此年龄段的健康儿童肺通气功能参数PEF、FVC、FEV、FEV1/FVC、MVV、FEF25、FEF50、FEF75、MMEF实测值占预计值百分比的正常参考值下限可考虑分别设为88.2%、88.4%、92.0%、94.4%、118.5%、82.9%、70.0%、62.1%、70.1%。

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