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  • Title: Amphotericin B dosage for disseminated candidiasis in premature infants.
    Author: Hall JE, Cox F, Karlson K, Robertson A.
    Journal: J Perinatol; 1987; 7(3):194-8. PubMed ID: 3332892.
    Abstract:
    Amphotericin B (Amp-B) serum concentrations were determined in five infants with disseminated candidiasis. All patients had positive blood cultures for Candida and one patient had Candida albicans meningitis. Amp-B sterilized the blood and the cerebrospinal fluid within four to nine days. Total doses of Amp-B varied from 11.6-62.3 mg. There was no laboratory or clinical evidence of renal toxicity. Two infants died of causes unrelated to disseminated candidiasis. Disseminated candidiasis in premature infants was treated successfully with 0.5 mg/kg doses of Amp-B, but further studies with more evaluable cases are needed to confirm the correct dose.
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