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  • Title: [Association between elevated blood pressure and high carotid intima-media thickness in children according to different blood pressure references].
    Author: Zhang LK, Zhang YQ, Zhang Q, Sun JH, Zhao M, Xi B.
    Journal: Zhonghua Yu Fang Yi Xue Za Zhi; 2020 Dec 06; 54(12):1396-1401. PubMed ID: 33333657.
    Abstract:
    Objective: To analyze the association between elevated blood pressure (BP) and carotid intima-media thickness (cIMT) in children according to four BP references. Methods: Study population came from"Huantai Childhood Cardiovascular Health Cohort Study"in Huantai County, Zibo City, Shandong Province. A convenient cluster sampling method was used to conduct a cross-sectional survey on 1 515 children from November 2017 to January 2018 in a primary school. A total of 1 431 children aged 6-11 years old with complete data were included in this study. Data on demographic characteristics, BP and cIMT were collected through questionnaire survey, physical examination and ultrasound examination. High cIMT was defined as the level of cIMT ≥ age-and sex-specific 90th percentile of this study population. Based on the Chinese Guideline reference, the Health Industry reference, the International reference and the U.S. reference, all participants were divided into three subgroups: the normal BP, high normal BP and, elevated BP. The multivariate logistic regression models were used to examine the association between BP status and high cIMT in children. Results: The age of children was (8.9±1.5) years, and boys accounted for 53.4% (n=682). The multivariate logistic regression models showed that after adjusting for relevant confounding factors, the risk of high cIMT in elevated BP group was increased compared with the normal BP group according to the four references (all P values<0.05) Conclusion: Elevated BP according to the four BP references is associated with high cIMT in children. 目的： 分析基于不同标准判定的儿童血压偏高与颈动脉内中膜（cIMT）增厚的关联。 方法： 研究对象来源于山东省淄博市桓台县开展的“桓台儿童心血管健康随访队列”。采用方便整群抽样的方法，于2017年11月至2018年1月在桓台县某所小学选取1 515名6~11岁儿童进行基线调查，最终纳入基线数据完整的研究对象共计1 431名。通过问卷调查、体格检查和超声检查收集一般人口学特征、血压、cIMT等信息。以cIMT≥本人群性别和年龄别的P90作为cIMT增厚的判定标准，同时分别基于中国3~17岁儿童血压参考标准（指南标准）、7~18岁儿童青少年血压偏高的筛查界值（行业标准）、6~17岁国际儿童血压参考标准（国际标准）和3~17岁美国儿童血压参考标准（美国标准）将基线期儿童血压分为正常血压、正常高值血压和血压偏高组，采用多因素logistic回归模型分析儿童血压与cIMT增厚的关联。 结果： 研究对象年龄为（8.9±1.5）岁，其中男生682名（53.4%）。多因素logistic回归模型分析结果显示，调整相关混杂因素后，与正常血压组相比，基于4种标准判定的血压偏高组cIMT增厚的风险均增加（P值均<0.05）。 结论： 基于4种血压标准判定的血压偏高与cIMT增厚均有关联。.
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