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  • Title: Primary capicua transcriptional repressor-rearranged sarcoma of the lung.
    Author: Mizukami Y, Takahashi Y, Sugita S, Wakabayashi K, Suzuki H, Hasegawa T, Noguchi H, Adachi H.
    Journal: Jpn J Clin Oncol; 2021 Apr 01; 51(4):654-656. PubMed ID: 33338234.
    Abstract:
    A 60-year-old man had a malignant left lower lung tumour with no metastases and underwent video-assisted thoracoscopic left lower lobectomy and lymphadenectomy. Pathological examination led to a diagnosis of capicua transcriptional repressor (CIC)-rearranged sarcoma. He has had 3.5 years of recurrence-free survival. CIC-rearranged sarcoma is a Ewing-like sarcoma that shows pathological findings similar to Ewing sarcoma. Most of CIC-rearranged sarcoma is CIC-double homeobox 4 protein (DUX4) fusion. Pulmonary CIC-rearranged sarcoma is extremely rare and has an unfavourable prognosis. However, complete resection can produce prognosis of long-term survival, and thus, surgery is an important option.
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