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  • Title: Pyrene dodecanoic acid coenzyme A ester: peroxisomal oxidation and chain shortening.
    Author: Gatt S, Bremer J, Osmundsen H.
    Journal: Biochim Biophys Acta; 1988 Jan 19; 958(1):130-3. PubMed ID: 3334862.
    Abstract:
    Pyrenedodecanoyl-CoA was beta-oxidized by isolated rat liver peroxisomes at a rate which was about 50% of that observed with palmitoyl-CoA. Measurement of the quantity of NADH formed from a limiting amount of pyrenedodecanoyl-CoA suggested that it was subjected to two to three cycles of beta-oxidation. Pyrenedodecanoyl-CoA was a very poor substrate for carnitine palmitoyltransferase, exhibiting less than 1% of the rate obtained with palmitoyl-CoA; it also was a strong inhibitor of this enzyme. With rat liver microsomal alpha-glycerophosphate acyltransferase the rate of reaction with pyrenedodecanoyl-CoA was only 3-4% of that observed with palmitoyl-CoA.
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