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  • Title: A Review of Accelerator-Produced Ga-68 with Solid Targets.
    Author: Becker KV, Chernysheva M, Barnhart TE, Gagnon K, Engle JW.
    Journal: Curr Radiopharm; 2021; 14(4):315-324. PubMed ID: 33357189.
    Abstract:
    Gallium-68 is a positron-emitting nuclide that has recently achieved clinical acceptance as the diagnostic radionuclide in PET tracers used for theranostic studies of lutetium-177 labeled therapeutic drugs due to the ease of access provided by germanium-68/gallium-68 generators. An alternative method of production currently being explored uses accelerators to form gallium-68 directly. This review of gallium-68 production strategies discusses available accelerator targetry at a range of beam energies and intensities, the many radiochemical separation techniques available to isolate Ga-68 from irradiated targets, isotopically enriched target material recovery, and the implications of these techniques for downstream radiolabeling applications.
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