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  • Title: COMPARATIVE MATHEMATICAL ANALYSIS OF COLONY-FORMING ABILITYOF THE BONE MARROW OF MICE LETHALLY AND NON-LETHALLY IRRADIATED WITH EQUAL DOSE RATE INTENSITY.
    Author: Boiko RV, Bilko DI, Russu IZ, Bilko NM.
    Journal: Probl Radiac Med Radiobiol; 2020 Dec; 25():300-308. PubMed ID: 33361842.
    Abstract:
    OBJECTIVE: To perform comparative analysis of the characteristics of population functioning process of mice bonemarrow colony-forming units after their prolonged irradiation in lethal and non-lethal doses with equal dose rateintensity with the aid of mathematical model. MATERIALS AND METHODS: Assigned task is solved by means of mathematical model of alterations in the number ofbone marrow colony-forming units after continuous irradiation, described in previous works, with the use of experimental results of K. S. Chertkov works (1972, 1973). Mathematical model is developed basing on the hematopoiesisscheme introduced by I. L. Chertkov (1984, 1991). RESULTS AND CONCLUSIONS: By applying original mathematical model, new scheme of hematopoiesis [6], with theuse of experimental results of γ-irradiation influence in the doses of 4 Gy and 8 Gy with the dose rate intensity of0.0028 Gy/min on the number of mice bone marrow colony-forming units, as well as experimental data concerningthe processes of their number recovery, obtained from literature references, we determined the parameters, whichcharacterize hematopoietic system reaction on the different stages of recovery processes of mice bone marrowcolony-forming units after the termination of ionizing radiation action; comparative analysis of obtained resultswas performed. Meta: provedennia porivnial'nogo analizu kharakterystyk protsesu funktsionuvannia populiatsiï koloniieutvoriuiuchykh odynyts' kistkovogo mozku mysheĭ pislia prolongovanogo ïkh oprominennia u letal'niĭ i neletal'niĭ dozakh zodnakovoiu potuzhnistiu doz za dopomogoiu matematychnoï modeli.Materialy i metody. Postavlena zadacha rozv’iazuiet'sia za dopomogoiu matematychnoï modeli zminy chysel'nosti koloniieutvoriuiuchykh odynyts' kistkovogo mozku pislia neperervnogo oprominennia, opysanoï v poperednikh robotakh, zvykorystanniam eksperymental'nykh rezul'tativ robit K. S. Chertkova (1972, 1973). Matematychna model' pobudovana na osnovi skhemy krovotvorennia, zaproponovanoï Ĭ. L. Chertkovym (1984, 1991).Rezul'taty ta vysnovky. Za dopomogoiu oryginal'noï matematychnoï modeli, novoï skhemy krovotvorennia Ĭ. L. Chertkova (1991) z vykorystanniam eksperymental'nykh rezul'tativ vplyvu γ-oprominennia v dozakh 4 Gr ta 8 Gr z potuzhnistiu 0,0028 Gr/khv na chysel'nist' koloniieutvoriuiuchykh odynyts' kistkovogo mozku mysheĭ, a takozh eksperymental'nykh danykh shchodo protsesiv vidnovlennia ïkhn'oï chysel'nosti, oderzhanykh z literaturnykh dzherel, vyznachenoparametry, shcho kharakteryzuiut' reaktsiiu krovotvornoï systemy na riznykh etapakh protsesiv vidnovlennia koloniieutvoriuiuchykh odynyts' kistkovogo mozku pislia prypynennia diï ionizuiuchoï radiatsiï, ta provedeno porivnial'nyĭ analiz otrymanykh rezul'tativ.
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