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Title: ENDOCRINE REGULATION OF ERYTHROID LINEAGE OF HEMATOPOIESIS IN CHILDREN LIVING UNDER A LOW-DOSE RADIATION EXPOSURE AFTER THE CHORNOBYL NPP ACCIDENT.
Author: Bebeshko VG, Bruslova KM, Boyarska OY, Lyashenko LO, Tsvyetkova NM, Gonchar LO, Chernysh TO, Trychlib IV, Pismenniy VD, Yaroshenko ZS, Vasylenko VV.
Journal: Probl Radiac Med Radiobiol; 2020 Dec; 25():374-389. PubMed ID: 33361848.
Abstract:
OBJECTIVE: Elucidation of relationship between the levels of thyroid-stimulating hormone (TSH), free serum thyroxine, serum and urine cortisol and parameters of erythroid lineage of hematopoiesis to estimate the thyroid functionin children of prepubertal, pubertal, and postpubertal age permanently residing under a low-dose radiation exposureto determine the premorbid state of thyroid function. MATERIALS AND METHODS: Children aged 3 to 18 years old (n = 203) living in the most intensively radionuclide-contaminated regions of Kyiv, Zhytomyr and Chornihiv oblasts of Ukraine after the Chornobyl NPP accident wereenrolled. Complaints of ossalgia, arthralgia, fatigue, bone fractures in the history, bone dysembryogenetic stigmata,hypermobility syndrome degree, and types of somatic diseases were taken into account. Peripheral blood countparameters, biochemical indices of blood serum were studied, namely the levels of total protein, cholesterol, creatinine and alkaline phosphatase activity. Levels of the free thyroxine, pituitary TSH, serum and daily urine cortisol, anddoses of radiation exposure were determined. RESULTS: The radiation dose values in children ranged from (0.35 ± 0.09) mSv to (0.54 ± 0.12) mSv. There was nodifference between the parameters of erythroid lineage of hematopoiesis depending on radiation dose. At the levels of serum TSH up to 1.0 μIU/ml no correlation was found with cortisol levels; at TSH levels of 1.0-3.0 μIU/ml thecorrelation coefficient was r = 0.31; at TSH levels higher than 3.0 μIU/ml the correlation coefficient was r = 0.61probably indicating a compensatory role of adrenal cortex in children at risk of thyroid disease development. In children with joint hypermobility grade II there was a higher incidence of dentofacial anomalies (χ2 = 6.9), deformitiesof lower extremities (χ2 = 6.9), and dental caries (χ2 = 4.3) (p < 0.05). There was a direct correlation between theserum TSH level (over 3 μIU/ml) and micrognathia (brachygnathia) (r = 0.62) indicating the impact of thyroid disease on dentofacial development. The TSH at a level of upper limit of the reference range values may contribute toa decreased RBC count in peripheral blood, increased average volume and hemoglobin content in erythrocyte beingassociated with the initial manifestations of thyroid dysfunction. CONCLUSIONS: Abnormal endocrine regulation of hematopoiesis affects the connective tissue, stromal microenvironment of bone marrow, and accordingly the erythroid branch of hematopoiesis in children, which may be relevant inthe development and course of oncohematological diseases. Meta: vyvchennia zv’iazku mizh rivniamy tyreotropnogo gormonu gipofizu, vil'nogo tyroksynu, kortyzolu v syrovattsikrovi ta kortyzolu v sechi i pokaznykamy erytrotsytarnoï lanky gemopoezu u diteĭ prepubertatnogo, pubertatnogo ta pisliapubertatnogo viku, iaki zhyvut' na radioaktyvno zabrudnenykh terytoriiakh pislia avariï na ChAES, dliaotsinky funktsional'nogo stanu shchytopodibnoï zalozy.Materialy i metody. Obstezheno 203 dytyny vikom vid 3 do 18 rokiv, iaki prozhyvaiut' v naĭbil'sh zabrudnenykhradionuklidamy regionakh Kyïvs'koï, Zhytomyrs'koï ta Chernigivs'koï oblasteĭ Ukraïny pislia avariï na Chornobyl's'kiĭ AES. U diteĭ vrakhovuvaly skargy na osalgiï, artralgiï, shvydku vtomu, perelomy kistok v anamnezi,kistkovi stygmy dyzembriogenezu, stupin' gipermobil'nogo syndromu, vyd somatychnoï patologiï. Vyvchaly pokaznyky peryferychnoï krovi, biokhimichni parametry syrovatky krovi: riven' zagal'nogo bilka, luzhnoï fosfatazy,kholesterynu, kreatyninu. Vyznachaly riven' vil'nogo tyroksynu, tyreotropnogo gormonu gipofizu (TTG), kortyzolu v syrovattsi krovi ta kortyzolu v doboviĭ sechi i dozy oprominennia diteĭ.Rezul'taty. Dozy oprominennia diteĭ kolyvalys' vid (0,35 ± 0,09) mZv do (0,54 ± 0,12) mZv. Ne bulo riznytsi mizhpokaznykamy erytrotsytarnoï lanky gemopozu zalezhno vid doz oprominennia. Pry rivniakh TTG v syrovattsi krovi do1,0 mkME/ml u diteĭ ne vstanovleno koreliatsiĭnogo zv’iazku z vmistom kortyzolu; pry rivniakh TTG 1,0 mkME/ml –3,0 mkME/ml koefitsiient koreliatsiï dorivniuvav r = 0,31; pry rivniakh TTG vyshchykh za 3,0 mkME/ml zv’iazok stanovyvr = 0,61, shcho mozhe svidchyty pro kompensatornu rol' kory nadnyrkovykh zaloz u diteĭ grupy ryzyku rozvytku z tyreoïdnoï patologiï. U diteĭ z II stupenem gipermobil'nosti suglobiv sposterigaiet'sia bil'sha chastota anomaliĭ zuboshchelepnoï systemy (χ2 = 6,9), deformatsiĭ nyzhnikh kintsivok (χ2 = 6,9) ta kariiesu zubiv (χ2 = 4,3), (r < 0,05). Vstanovlenyĭ priamyĭ koreliatsiĭnyĭ zv’iazok mizh rivnem TTG v syrovattsi krovi (vyshchyĭ za 3,0 mkME/ml) i nedorozvynutoiu shchelepoiu u diteĭ (r = 0,62), shcho svidchyt' pro vplyv tyreoïdnoï patologiï na rozvytok zuboshchelepnogo aparatu. Riven' TTG, iakyĭ znakhodyvsia na verkhniĭ mezhi referentnykh znachen', mozhe spryiaty zmenshenniu chysla erytrotsytiv v krovi, pidvyshchenniu seredn'ogo ob’iemu ta vmistu gemoglobinu v erytrotsyti, shcho pov’iazano z pochatkovymyproiavamy porushennia funktsional'nogo stanu tyreoïdnoï systemy.Vysnovky. Naiavnist' zmin v endokrynniĭ reguliatsiï gemopoezu vplyvaie na stan spoluchnoï tkanyny, stromal'nogo mikrootochennia kistkovogo mozku diteĭ i, vidpovidno, erytrotsytarnu lanku krovotvorennia, shcho mozhe vidigravaty rol' u rozvytku ta perebigu onkogematologichnoï patologiï.

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