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  • Title: Biogenesis and discharge of the rhoptries: Key organelles for entry and hijack of host cells by the Apicomplexa.
    Author: Ben Chaabene R, Lentini G, Soldati-Favre D.
    Journal: Mol Microbiol; 2021 Mar; 115(3):453-465. PubMed ID: 33368727.
    Abstract:
    Rhoptries are specialized secretory organelles found in the Apicomplexa phylum, playing a central role in the establishment of parasitism. The rhoptry content includes membranous as well as proteinaceous materials that are discharged into the host cell in a regulated fashion during parasite entry. A set of rhoptry neck proteins form a RON complex that critically participates in the moving junction formation during invasion. Some of the rhoptry bulb proteins are associated with the membranous materials and contribute to the formation of the parasitophorous vacuole membrane while others are targeted into the host cell including the nucleus to subvert cellular functions. Here, we review the recent studies on Toxoplasma and Plasmodium parasites that shed light on the key steps leading to rhoptry biogenesis, trafficking, and discharge.
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