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  • Title: Quarternary α-cyanobenzylsulfonamides: A new subclass of CAA fungicides with excellent anti-Oomycetes activity.
    Author: Stierli D, Eberle M, Lamberth C, Jacob O, Balmer D, Gulder T.
    Journal: Bioorg Med Chem; 2021 Jan 15; 30():115965. PubMed ID: 33373819.
    Abstract:
    A bioisosteric carboxamide - sulfonamide replacement explored during the optimization of an insecticide lead compound led to the surprising discovery of a formerly unknown subclass of the Carboxylic Acid Amide (CAA) fungicides, which is the very first CAA fungicide group without a carboxamide function. In this paper we present invention pathway, racemic and stereoselective synthesis routes, structure-activity relationship studies as well as resistance profile of this novel family of fungicides.
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