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  • Title: [Complete change of the cell composition of the liver parenchyma following exposure to dipin and partial resection].
    Author: Uryvaeva IV, Faktor VM.
    Journal: Biull Eksp Biol Med; 1988 Jan; 105(1):77-80. PubMed ID: 3337887.
    Abstract:
    The phenomenon of total replacement of preexisting and damaged hepatocytes in mice were demonstrated by the method of autoradiography. Adult mice were injected an alkylating drug Dipin 2 h prior to partial hepatectomy and then proliferating cells were labelled by means of multiple injections of 14C-thymidine. Dipin in combination with mitotic stimulation induced multiple mitotic aberrations in proliferating hepatocytes resulting in degeneration, death and then elimination of prelabelled liver cells. New parenchymal tissue originated from non-labelled preneoplastic nodules. These hepatocyte nodules grew in size, propagated and 8-10 months later completely replaced the preexisting hepatocytes.
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