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  • Title: Coexisting antibiotic changes the persistence and metabolic profile of atrazine in the environment.
    Author: Jiang W, Zhai W, Liu D, Wang P.
    Journal: Chemosphere; 2021 Apr; 269():129333. PubMed ID: 33385668.
    Abstract:
    Pesticides are widely used in agriculture to control weeds, pests and plant diseases. Antibiotics may be introduced to the agricultural environment by manure fertilizer or wastewater irrigation. Co-existence of antibiotics in field may lead to profound impacts on pesticide residue. In this study, the impacts of oxytetracycline on the environmental fate and metabolic profile of atrazine was investigated, and the disturbance of oxytetracycline on functional genes related to atrazine degradation in soils was also studied. Oxytetracycline could inhibit the degradation of atrazine significantly and prolong the half-life to 1.27 and 1.59 times longer at 5 mg/kg and 50 mg/kg. Also, oxytetracycline altered the composition of atrazine metabolites, including three chloro-s-triazine metabolites (DEA, DIA, DDA) and three hydroxyl metabolites (OH-ATZ, OH-DEA, OH-DIA). Oxytetracycline decreased the ratio of hydroxyl metabolites, while increased the chloro-s-triazine metabolites which had higher toxicity and were easily leached in soil. Atrazine hydrolase genes atzA and trzN were down-regulated by oxytetracycline, which might decrease the hydroxyl metabolite formation and detoxification of atrazine. Oxytetracycline changed the degradation of atrazine and the composition of the metabolites probably by altering the soil microorganisms. The increased persistence and the percentage of the chloro-s-triazine metabolites induced by oxytetracycline might result in increased environmental problems.
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