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  • Title: Bioactive cyclohexene derivatives from a mangrove-derived fungus Cladosporium sp. JJM22.
    Author: Zhang B, Wu JT, Zheng CJ, Zhou XM, Yu ZX, Li WS, Chen GY, Zhu GY.
    Journal: Fitoterapia; 2021 Mar; 149():104823. PubMed ID: 33387642.
    Abstract:
    Four new cyclohexene derivatives cladoscyclitols A-D (1-4) and one new ribofuranose phenol derivative 4-O-α-D-ribofuranose-2-pentyl-3-phemethylol (5) were obtained from the EtOAC extract of the mangrove-derived endophytic fungus Cladosporium sp. JJM22. The structures were elucidated by extensive NMR and MS analysis, while the absolute configurations of the stereogenic carbons were established based on quantum-chemical electronic circular dichroism calculations or comparison of the optical rotations with those of related compounds. Compounds 2 and 5 displayed potent inhibitory activity against α-glucosidase with the IC50 values of 2.95 and 2.05 μM, respectively.
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