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  • Title: Relapse of herpes simplex encephalitis after conventional acyclovir therapy.
    Author: VanLandingham KE, Marsteller HB, Ross GW, Hayden FG.
    Journal: JAMA; 1988 Feb 19; 259(7):1051-3. PubMed ID: 3339802.
    Abstract:
    Acyclovir sodium is the drug of choice for the treatment of herpes simplex encephalitis. We treated an immunocompetent patient with a ten-day course of intravenous acyclovir sodium at the recommended dosage of 10 mg/kg every eight hours for clinically apparent herpes simplex encephalitis. After marked improvement, his condition deteriorated four days after completing acyclovir therapy. A subsequent brain biopsy specimen disclosed acyclovir-sensitive herpes simplex virus type 1. A longer duration of acyclovir therapy (14 to 21 days) should be considered for treating herpes simplex encephalitis.
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