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  • Title: Carcinoembryonic antigen: immunohistologic identification in invasive and intraepithelial carcinomas of the lung.
    Author: Pascal RR, Mesa-Tejada R, Bennett SJ, Garces A, Fenoglio CM.
    Journal: Arch Pathol Lab Med; 1977 Nov; 101(11):568-71. PubMed ID: 334106.
    Abstract:
    A total of 58 pulmonary lesions from 48 patients were examined for carcinoembryonic antigen (CEA). The three-layer immunoperoxidase procedure for antigen detection was used with a monospecific anti-CEA antiserum. The control serum was the same antiserum with its specificity removed by affinity chromatography. Normal goat serum was also used as a control. Carcinoembryonic antigen was present in the majority of pulmonary adenocarcinomas and generally absent in the squamous cancers. The major exception was in the well-differentiated squamous lesions where CEA was occasionally found in the keratinizing areas. Of special interest was the finding of CEA in all areas of intraepithelial squamous neoplasia studied.
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