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  • Title: Functional connectivity of the nucleus basalis of Meynert in Lewy body dementia and Alzheimer's disease.
    Author: Schumacher J, Thomas AJ, Peraza LR, Firbank M, O'Brien JT, Taylor JP.
    Journal: Int Psychogeriatr; 2021 Jan; 33(1):89-94. PubMed ID: 33413710.
    Abstract:
    Cholinergic deficits are a hallmark of Alzheimer's disease (AD) and Lewy body dementia (LBD). The nucleus basalis of Meynert (NBM) provides the major source of cortical cholinergic input; studying its functional connectivity might, therefore, provide a tool for probing the cholinergic system and its degeneration in neurodegenerative diseases. Forty-six LBD patients, 29 AD patients, and 31 healthy age-matched controls underwent resting-state functional magnetic resonance imaging (fMRI). A seed-based analysis was applied with seeds in the left and right NBM to assess functional connectivity between the NBM and the rest of the brain. We found a shift from anticorrelation in controls to positive correlations in LBD between the right/left NBM and clusters in right/left occipital cortex. Our results indicate that there is an imbalance in functional connectivity between the NBM and primary visual areas in LBD, which provides new insights into alterations within a part of the corticopetal cholinergic system that go beyond structural changes.
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