These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The frequency of aneuploidy in prenatally diagnosed congenital heart disease: an indication for fetal karyotyping.
    Author: Copel JA, Cullen M, Green JJ, Mahoney MJ, Hobbins JC, Kleinman CS.
    Journal: Am J Obstet Gynecol; 1988 Feb; 158(2):409-13. PubMed ID: 3341415.
    Abstract:
    The frequency of chromosomal abnormalities in infants with congenital heart disease has been estimated from postnatal clinic data to be 5% to 10%. Over an 18-month period we performed fetal echocardiograms on 502 fetuses and found cardiac anomalies in 34. Eleven of these fetuses (32%) had abnormal chromosomes. This marked discrepancy from the data found in the pediatric literature may relate to nonviable fetuses identified in utero, who escape pediatric case identification. We conclude that in cases of fetal heart disease the workup should include either amniocentesis or fetal blood sampling for chromosome analysis. The information can be used for complete parental counseling and for managing delivery and neonatal care.
    [Abstract] [Full Text] [Related] [New Search]