These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Kinetic evidence for heterogeneity in Na+-D-glucose cotransport systems in the normal human fetal small intestine.
    Author: Malo C.
    Journal: Biochim Biophys Acta; 1988 Feb 18; 938(2):181-8. PubMed ID: 3342230.
    Abstract:
    Zero-trans kinetic studies of Na+-D-glucose cotransport have been performed under voltage-clamped conditions in brush-border membrane vesicles isolated from both jejunum and ileum of 17-20-week-old normal human fetuses. Varying glucose concentrations in the incubation medium led to curvilinear Eadie-Hofstee plots in the jejunum only, thus suggesting the presence of both high-affinity, low-capacity (Km 0.37 mM; Vmax 8.3 nmol/min per mg protein) and low-affinity, high-capacity (Km 4.2 mM; Vmax 30.9 nmol/min per mg protein) systems in the proximal small intestine, and of a single carrier (Km 1.2 mM; Vmax 4.9 nmol/min per mg protein) in the distal small intestine. Sodium activation curves provide further evidence for heterogeneity in glucose transport systems in the fetal small intestine: Hill coefficients of 2 and 1 were found for the jejunal high-affinity and ileal systems, and for the jejunal low-affinity system, respectively. It is concluded that there is early differentiation of a functional heterogeneity in glucose transport capacity along the human fetal small intestine.
    [Abstract] [Full Text] [Related] [New Search]