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  • Title: Videotape technique in assessing antidepressants.
    Author: Little JC, McClelland HA, Kerr TA.
    Journal: Br J Clin Pharmacol; 1977; 4Suppl 2(Suppl 2):227S-232S. PubMed ID: 334228.
    Abstract:
    1 In the search for superior levels of objectivity in research in clinical psychiatry videotape (VT), recordings were made of all clinical interviews with the first eleven patients entering a double-blind controlled trial of antidepressant drugs. 2 The treating psychiatrist recorded diagnosis as listed in the ICD and described in its accompanying Glossary, and rated the Hamilton Depression Scale (HDS) at pretreatment and final interviews. A Visual Analogue Scale (VAS) for depression was independently scored by psychiatrist and patient at each interview. 3 VT recordings were despatched for independent repetition of diagnostic assessment and ratings of mood (HDS and VAS) by two further psychiatrists, creating in effect a multiple-blind study. 4 Agreement was satisfactory on ICD listed diagnoses and complete for the broad category of `affective disorder'. 5 Between the three psychiatrists, there was a high correlation of HDS scores. Patients were independently agreed to form a group of moderately depressed subjects. Closely related degrees of improvement were recorded by the three psychiatrists in all patients. 6 Correlation of scores were high for the VAS for depression as independently scored by patient, treating psychiatrist and the two VT viewers. 7 The VAS was shown to be a simple, quick and reliable indicator of depressive mood suited to repeated use at short intervals. 8 VT recordings are a useful tool in the search for higher levels of objectivity in clinical research. The technique described might well become as accepted in psychiatric drug trials as the blind control procedure.
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