These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A clinical comparison of nomifensine and amitriptyline.
    Author: McClelland HA, Kerr TA, Little JC.
    Journal: Br J Clin Pharmacol; 1977; 4Suppl 2(Suppl 2):233S-236S. PubMed ID: 334229.
    Abstract:
    1. The study consists of a double-blind evaluation of nomifensine and amitriptyline in a group of 37 patients with primary depressive illness. 2. The patients were referred by their family doctors on the basis that they would ordinarily have been prescribed a tricyclic antidepressant drug. Random allocation to the treatment groups took place. Assessment took place at weekly intervals over a 4-week period using the Visual Analogue Scale for depression and anxiety, and a side-effects check-list. Patients were also assessed on the Hamilton Depression Scale before the onset and at the end of the trial. 3. No significant difference was found between the two groups as regards relief from depression and anxiety, although marginal differences were found in favour of the amitriptyline group. 4. The overall frequency of side-effects was similar in the nomifensine and amitriptyline patients, But the development of severe side-effects was significantly more common in the amitriptyline group.
    [Abstract] [Full Text] [Related] [New Search]