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  • Title: [Idiopathic cold agglutinin disease. Clinical aspects, therapy and course in 6 patients].
    Author: Budmiger H, Rhyner K, Siegenthaler-Zuber G, Bollinger A.
    Journal: Schweiz Med Wochenschr; 1988 Jan 16; 118(2):52-7. PubMed ID: 3344409.
    Abstract:
    Clinical features, diagnostic procedure, therapy, course of the disease and prognosis in 6 patients with severe idiopathic chronic cold agglutinin disease are described. In 5 patients the main complaint was cold mediated acrocyanosis. The cold agglutinin in all patients was of anti-I type and belonged to IgM immunoglobulin. Keeping warm provided symptomatic relief and the hemolysis decreased to a milder form. Treatment with glucocorticoids alone failed in two patients but succeeded in combination with chlorambucil or cyclophosphamid. One patient developed a lymphoproliferative disorder 11 years after diagnosis of idiopathic chronic cold agglutinin disease.
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