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  • Title: Novel γ-cyclodextrin-metal-organic frameworks for encapsulation of curcumin with improved loading capacity, physicochemical stability and controlled release properties.
    Author: Chen Y, Tai K, Ma P, Su J, Dong W, Gao Y, Mao L, Liu J, Yuan F.
    Journal: Food Chem; 2021 Jun 15; 347():128978. PubMed ID: 33444890.
    Abstract:
    A safe and biodegradable γ-cyclodextrin-metal-organic-frameworks (γ-CD-MOFs) was successfully synthesized by using an improved hydrothermal method. In this study, curcumin (Cur) was chosen for testing the encapsulation stability and release performance of γ-CD-MOFs. Results of the crystal structure measurement indicated that the encapsulated curcumin within γ-CD-MOFs via van der Waals forces, hydrophobic interactions and hydrogen bonding was failed to disturb the inherent microtopography and crystallinity of γ-CD-MOFs. Compared to individual γ-CD, the γ-CD-MOFs exhibited improved loading capacity, physicochemical stability as well as controlled-release property in simulated digestion, and hence can be regarded as effective carriers for curcumin. Curcumin-loaded γ-CD-MOFs with a Cur : γ-CD-MOFs mass ratio of 2:3 (Cur-CD-MOFs/3), which showed the highest encapsulation efficiency (67.31 ± 2.25%), improved physicochemical stability and controlled-release performance, was selected for further research and industrialization. Our results demonstrate that γ-CD-MOFs can be regarded as a promising novel carrier for the delivery of curcumin or other hydrophobic nutraceuticals.
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