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  • Title: Veno-occlusive disease of the liver in captive cheetah.
    Author: Gosselin SJ, Loudy DL, Tarr MJ, Balistreri WF, Setchell KD, Johnston JO, Kramer LW, Dresser BL.
    Journal: Vet Pathol; 1988 Jan; 25(1):48-57. PubMed ID: 3344570.
    Abstract:
    Liver tissues from 126 captive cheetah were evaluated by light microscopy and histochemistry; eight animals were evaluated by electron microscopy. The main hepatic lesion, a vascular lesion resembling veno-occlusive disease (VOD) of the liver and characterized by subendothelial fibrosis and proliferation of smooth muscle-like cells in the central veins, was seen in 60% of the sexually mature cheetah. Although this hepatic vascular lesion was seen in cheetah as young as 1 year of age, the most severe lesions, usually associated with liver failure, were found in cheetah between the ages of 6 and 11. There was no sex predisposition, and in approximately 40% of the VOD cases, liver disease was not suspected clinically or at necropsy. VOD was found in other felidae, especially in the snow leopard. High levels of vitamin A in livers, as well as in diets of the cheetah, could be a contributing factor in the development of VOD in some groups of cheetah.
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