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  • Title: Radionuclide exploration of dialysis amyloidosis: preliminary experience.
    Author: Grateau G, Zingraff J, Fauchet M, Mundler O, Raymond P, Berthelot JM, Bardin T, Kuntz D, Drüeke T.
    Journal: Am J Kidney Dis; 1988 Mar; 11(3):231-7. PubMed ID: 3344746.
    Abstract:
    The noninvasive diagnosis of amyloid arthropathy in dialysis patients is still uncertain. Therefore, we investigated the potential diagnostic value of the 99mTc-methylene diphosphonate scan in seven long-term hemodialysis patients suffering from chronic joint pain who had biopsy-proven osteoarticular amyloidosis of the recently discovered beta 2-microglobulin (beta 2-M) type. In six, but in none of five control patients on short-term hemodialysis, increased tracer uptake was found at the site of one or several articular and/or periarticular regions. Increased uptake at a given joint was often, but not always, associated with joint pain. It appeared to precede radiologically visible changes. In conclusion, the 99mTc-methylene diphosphonate scan may be of help in the early diagnosis of dialysis amyloidosis.
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