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  • Title: Delivery of Interleukin 4 from a Titanium Substrate Coated with Graphene Oxide for Enhanced Osseointegration by Regulating Macrophage Polarization.
    Author: Li Q, Liang B, Wang F, Wang Z.
    Journal: ACS Biomater Sci Eng; 2020 Sep 14; 6(9):5215-5229. PubMed ID: 33455271.
    Abstract:
    Macrophage-related inflammation has been identified as a possible predictor of the success or failure of implants based on their polarization of the pro-inflammatory/anti-inflammatory (M1/M2) phenotype. The purpose of this study was to deliver interleukin 4 (IL-4, a cytokine that triggers M2 polarization of macrophages) from a titanium substrate by a graphene oxide (GO) coating to regulate the macrophage-related inflammatory response and improve the implant performance. The GO/IL-4 coating showed good biocompatibility and promoted macrophages polarization to the M2 phenotype in vitro. Conditioned media from macrophages cultured on a GO/IL-4 surface promoted the proliferation, migration, and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). As the inflammatory response at the interface of GO/IL-4 weakened, the percentage of M2-polarized macrophages increased and the best stability, bone-implant contact, and osteogenesis were observed in vivo. These results demonstrate that the macrophage-related inflammatory response plays a crucial role in osteogenesis around implants and that this GO/IL-4 coating provides an effective strategy for promoting implant osseointegration by regulating immune function.
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