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  • Title: Rapid progression of chronic active type B hepatitis in a patient with hypogammaglobulinemia.
    Author: Tong MJ, Nies KM, Redeker AG.
    Journal: Gastroenterology; 1977 Dec; 73(6):1418-21. PubMed ID: 334624.
    Abstract:
    Rapid progression of acute type B hepatitis to chronic active liver disease and cirrhosis in a young male with hypogammaglobulinemia is described. Absent circulating IgA, significantly low IgG, and normal IgM levels were detected during the acute phase of illness. Enumeration of peripheral lymphocytes revealed a decreased number of T cells and normal numbers of B cells. In vitro pokeweed stimulation of Ig synthesis correlated with the in vivo circulating levels of the three immunoglobulins. Cell-mediated immune responses were normal except for lymphocyte stimulation to hepatitis B surface antigen. It was concluded that the defective synthesis of IgG and IgA antibodies to hepatitis B surface antigen contributed to the accelerated progression to chronic active type B hepatitis in this person.
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