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  • Title: [A Case of Large Cell Neuroendocrine Carcinoma of the Ampulla of Vater].
    Author: Hatakeyama T, Sakai K, Komiyama S, Tamai H, Ogino S, Akami T, Ueda Y, Mazaki T.
    Journal: Gan To Kagaku Ryoho; 2020 Dec; 47(13):2400-2402. PubMed ID: 33468974.
    Abstract:
    An 80-year-old women admitted to our hospital with jaundice. Abdominal contrast-enhanced CT scan revealed an enhanced tumor, measuring 10 mm, at the duodenal ampulla. Upper endoscopy showed a submucosal tumor-like lesion at the duodenal ampulla. Immunohistochemical findings showed positive for chromogranin A and synaptophysin, and neuroendocrine carcinoma was diagnosed. Subtotal stomach-preserving pancreaticoduodenectomy with regional lymph node dissection was performed. The final diagnosis was large cell neuroendocrine carcinoma(LCNEC). Multiple metastases of liver, lung and bone were occurred 14 months after the surgery, and she died 21 months after the surgery. LCNEC of the duodenal ampulla is very rare, and its prognosis is poor.
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