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  • Title: Redistribution of lipofuscin in aged neurons induced by colchicine.
    Author: Gorenstein C, Roberts VJ, Bundman MC.
    Journal: Mech Ageing Dev; 1988 Jan; 42(1):63-73. PubMed ID: 3347098.
    Abstract:
    The effect of a single, 40 micrograms, intracerebroventricular injection of colchicine on the distribution of neuronal lysosomes and lipofuscin granules in aged mice was studied. At the light microscope level we observed that colchicine induced a redistribution of dipeptidyl aminopeptidase II (Dpp II), a lysosomal and lipofuscin granule marker enzyme, from the cell bodies of neurons to the dendrites; cell bodies became depleted of Dpp II while dendrites became enriched with this enzyme. Quantitation of this phenomenon at the electron microscope level demonstrated that colchicine induced a rapid and significant decrease in the density of lysosomes and lipofuscin granules from the somata of neurons whereas in dendrites we observed a significant increase in the density of these organelles.
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