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  • Title: Phenotype and Genotype Study of Novel C480F Maribavir-Ganciclovir Cross-Resistance Mutation Detected in Hematopoietic Stem Cell and Solid Organ Transplant Recipients.
    Author: Santos Bravo M, Plault N, Sánchez Palomino S, Mosquera Gutierrez MM, Fernández Avilés F, Suarez Lledo M, Sabé Fernández N, Rovira M, Alain S, Marcos Maeso MÁ.
    Journal: J Infect Dis; 2021 Sep 17; 224(6):1024-1028. PubMed ID: 33475730.
    Abstract:
    Two transplant recipients (1 kidney and 1 hematopoietic stem cell) received maribavir (MBV) after cytomegalovirus (CMV) infection clinically resistant to standard therapy. Both patients achieved CMV DNA clearance within 30 and 18 days; however, the UL97 C480F variant emerged, causing recurrent CMV infection after a cumulative 2 months of MBV and 15 or 4 weeks of ganciclovir treatment, respectively. C480F was not detected under ganciclovir before MBV treatment. Recombinant phenotyping showed that C480F conferred the highest level of MBV resistance and ganciclovir cross-resistance, with impaired viral growth. Clinical follow-up and genotypic and phenotypic studies are essential for the assessment and optimization of patients with suspected MBV resistance.
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