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  • Title: Selective Catalytic Synthesis of α-Alkylated Ketones and β-Disubstituted Ketones via Acceptorless Dehydrogenative Cross-Coupling of Alcohols.
    Author: Bhattacharyya D, Sarmah BK, Nandi S, Srivastava HK, Das A.
    Journal: Org Lett; 2021 Feb 05; 23(3):869-875. PubMed ID: 33476162.
    Abstract:
    Herein, a phosphine-free pincer ruthenium(III) catalyzed β-alkylation of secondary alcohols with primary alcohols to α-alkylated ketones and two different secondary alcohols to β-branched ketones are reported. Notably, this transformation is environmentally benign and atom efficient with H2O and H2 gas as the only byproducts. The protocol is extended to gram-scale reaction and for functionalization of complex vitamin E and cholesterol derivatives.
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