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  • Title: Progress in the Enantioseparation of β-Blockers by Chromatographic Methods.
    Author: Yang Y, Wang Y, Bao Z, Yang Q, Zhang Z, Ren Q.
    Journal: Molecules; 2021 Jan 17; 26(2):. PubMed ID: 33477385.
    Abstract:
    β-adrenergic antagonists (β-blockers) with at least one chiral center are an exceedingly important class of drugs used mostly to treat cardiovascular diseases. At least 70 β-blockers have been investigated in history. However, only a few β-blockers, e.g., timolol, are clinically marketed as an optically pure enantiomer. Therefore, the separation of racemates of β-blockers is essential both in the laboratory and industry. Many approaches have been explored to obtain the single enantiomeric β-blocker, including high performance liquid chromatography, supercritical fluid chromatography and simulated moving bed chromatography. In this article, a review is presented on different chromatographic methods applied for the enantioseparation of β-blockers, covering high performance liquid chromatography (HPLC), supercritical fluid chromatography (SFC) and simulated moving bed chromatography (SMB).
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