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  • Title: Urinary C-peptide in the neonate correlates both to maternal glucose tolerance and to fetal size at birth.
    Author: Lunell NO, Persson B, Devarajan LV, Hassan S, Hathout H, Kasrawi R, Saleh A, Viktorin L.
    Journal: Am J Perinatol; 1988 Apr; 5(2):144-5. PubMed ID: 3348860.
    Abstract:
    In 18 women with gestational diabetes the variables of an oral glucose tolerance test (fasting and 2-hour blood glucose values and area under the blood glucose curve) performed in the last trimester of pregnancy correlated significantly with the urinary C-peptide excretion during the first 12 hours of the life (r = 0.47, 0.71, and 0.60, respectively). In a combined group with 28 type II pregnant diabetic women there was also a significant correlation between the urinary C-peptide excretion of the infants and their skinfold. Assay of the urinary C-peptide excretion of the neonate, reflecting its insulin production, seems to be a sensitive parameter to study the influence of the maternal carbohydrate metabolism in the offspring.
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