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  • Title: Electron conduction between b cytochromes of the mitochondrial respiratory chain in the presence of antimycin plus myxothiazol.
    Author: West IC, Mitchell P, Rich PR.
    Journal: Biochim Biophys Acta; 1988 Mar 30; 933(1):35-41. PubMed ID: 3349068.
    Abstract:
    The b haems of the bc1 complex of bovine heart mitochondria were poised with succinate and fumarate so that only the high-potential haem (b-562) was reduced, and then isolated from further redox exchange with the ubiquinone pool by adding antimycin and myxothiazol. A transmembrane electric potential difference was then developed, either by electron flow from [Ru(NH3)6]Cl2 to oxygen or by ATP hydrolysis. The small difference spectrum, caused by the electric field, indicated 32-55% oxidation of b-562 with concomitant reduction of b-566. No lag greater than 0.1 s was detectable between the initiation of respiration and the development of the difference spectrum, thus providing a direct demonstration of (fairly) rapid electron transfer between the b haems.
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