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  • Title: Structure and regulation of human phospholipase D.
    Author: Bowling FZ, Frohman MA, Airola MV.
    Journal: Adv Biol Regul; 2021 Jan; 79():100783. PubMed ID: 33495125.
    Abstract:
    Mammalian phospholipase D (PLD) generates phosphatidic acid, a dynamic lipid secondary messenger involved with a broad spectrum of cellular functions including but not limited to metabolism, migration, and exocytosis. As a promising pharmaceutical target, the biochemical properties of PLD have been well characterized. This has led to the recent crystal structures of human PLD1 and PLD2, the development of PLD specific pharmacological inhibitors, and the identification of cellular regulators of PLD. In this review, we discuss the PLD1 and PLD2 structures, PLD inhibition by small molecules, and the regulation of PLD activity by effector proteins and lipids.
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