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  • Title: The binding of [3H]telenzepine to muscarinic acetylcholine receptors in calf forebrain.
    Author: Schudt C, Auriga C, Kinder B, Birdsall NJ.
    Journal: Eur J Pharmacol; 1988 Jan 05; 145(1):87-90. PubMed ID: 3350039.
    Abstract:
    Telenzepine binds to calf brain muscarinic receptors with a selectivity for M1 receptors that is comparable to that exhibited by pirenzepine. Telenzepine has a 10-fold higher affinity than pirenzepine at these receptors and is equipotent with atropine. Because of its potency, selectivity and hydrophilicity, [3H]telenzepine is an excellent radioligand for binding to and monitoring M1 receptor binding sites. The kinetics of [3H]telenzepine binding are extremely slow, even at 37 degrees C.
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