These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Central and peripheral hypotensive effects of the optical isomers of nicardipine, a dihydropyridine calcium channel antagonist, in rats.
    Author: Brisac AM, Champéroux P, Lucet B, Laurent S, Schmitt H.
    Journal: Eur J Pharmacol; 1988 Jan 27; 146(1):171-4. PubMed ID: 3350056.
    Abstract:
    Central and peripheral hypotensive effects of (+)- and (-)-nicardipine (1-10 micrograms/kg i.v. or i.c.v.) were investigated in normotensive and SH rats. The results suggest that a stereoselectivity exists for the peripheral and central hypotensive effects of the nicardipine isomers. (+)-Nicardipine was shown to be 3-8 times as potent as the (-) isomer in reducing blood pressure in all the experiments.
    [Abstract] [Full Text] [Related] [New Search]