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  • Title: [Prognostic significance of lacunar lesions in magnetic resonance tomography in multiple sclerosis].
    Author: Weihe W, Manke A, Gowin W, Mariss G, Welter FL.
    Journal: Nervenarzt; 1988 Jan; 59(1):14-8. PubMed ID: 3352842.
    Abstract:
    175 patients with definite multiple sclerosis underwent nuclear magnetic resonance imaging. T1-weighted images showed in 59 patients (34%) periventricular lesions with a central area of decreased signal intensity. They appear as lacunar defects in the walls of the lateral ventricle system. In accordance with neuropathological findings we suggest that in these plaques a cystic degeneration has replaced gliosis. Patients with cystic defects are characterized by a high activity of the disease (e.d. increased annual production of plaques) and a poor prognosis. Lacunae are found in the early stages of the disease and provide a prognostic sign in multiple sclerosis.
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